摘要
No AccessJournal of UrologyInvestigative Urology1 Apr 2015Olfactory System of Highly Trained Dogs Detects Prostate Cancer in Urine Samples Gianluigi Taverna, Lorenzo Tidu, Fabio Grizzi, Valter Torri, Alberto Mandressi, Paolo Sardella, Giuseppe La Torre, Giampiero Cocciolone, Mauro Seveso, Guido Giusti, Rodolfo Hurle, Armando Santoro, and Pierpaolo Graziotti Gianluigi TavernaGianluigi Taverna Humanitas Clinical and Research Center, Rozzano, Milan, Italy , Lorenzo TiduLorenzo Tidu Italian Ministry of Defense Military Veterinary Center, Grosseto, Milan, Italy , Fabio GrizziFabio Grizzi Humanitas Clinical and Research Center, Rozzano, Milan, Italy , Valter TorriValter Torri Istituto di Ricovero e Cura a Carattere Scientifico, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy , Alberto MandressiAlberto Mandressi Humanitas Clinical and Research Center, Rozzano, Milan, Italy , Paolo SardellaPaolo Sardella Italian Ministry of Defense Military Veterinary Center, Grosseto, Milan, Italy , Giuseppe La TorreGiuseppe La Torre Italian Ministry of Defense Military Veterinary Center, Grosseto, Milan, Italy , Giampiero CoccioloneGiampiero Cocciolone Italian Ministry of Defense Military Veterinary Center, Grosseto, Milan, Italy , Mauro SevesoMauro Seveso Humanitas Clinical and Research Center, Rozzano, Milan, Italy , Guido GiustiGuido Giusti Humanitas Clinical and Research Center, Rozzano, Milan, Italy , Rodolfo HurleRodolfo Hurle Humanitas Clinical and Research Center, Rozzano, Milan, Italy , Armando SantoroArmando Santoro Humanitas Clinical and Research Center, Rozzano, Milan, Italy , and Pierpaolo GraziottiPierpaolo Graziotti Humanitas Clinical and Research Center, Rozzano, Milan, Italy View All Author Informationhttps://doi.org/10.1016/j.juro.2014.09.099AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We established diagnostic accuracy in terms of the sensitivity and specificity with which a rigorously trained canine olfactory system could recognize specific volatile organic compounds of prostate cancer in urine samples. Materials and Methods: Two 3-year-old female German Shepherd Explosion Detection Dogs were trained to identify prostate cancer specific volatile organic compounds in urine samples. They were tested on 362 patients with prostate cancer (range low risk to metastatic) and on 540 healthy controls with no nonneoplastic disease or nonprostatic tumor. This cross-sectional design for diagnostic accuracy was performed at a single Italian teaching hospital and at the Italian Ministry of Defense Military Veterinary Center. Results: For dog 1 sensitivity was 100% (95% CI 99.0–100.0) and specificity was 98.7% (95% CI 97.3–99.5). For dog 2 sensitivity was 98.6% (95% CI 96.8–99.6) and specificity was 97.6% (95% CI 95.9–98.7). When considering only men older than 45 years in the control group, dog 1 achieved 100% sensitivity and 98% specificity (95% CI 96–99.2), and dog 2 achieved 98.6% sensitivity (95% CI 96.8–99.6) and 96.4% specificity (95% CI 93.9–98.1). 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Prof. Loraine Willis provided linguistic revision. Profs. Hywel Williams, Nicola Portinaro, Giuseppe Lippi and Aldo Maggioni, and Drs. Lidia Rota-Vender, Luca Balzarini, Salvatore Badalamenti, Fabio Baticci, Michele La Gioia, Michele Tedeschi and Alberto Trinchieri provided comments. Gens. di Corpo d'Armata Claudio Graziano, Piervalerio Manfroni and Gen. Federico Marmo, Ten. Cols. Mario Marchisio and Paolo Di Bona, Col. Luca Virgilio and Gen. Gianfranco Giardella provided technical support.MetricsAuthor Information Gianluigi Taverna Humanitas Clinical and Research Center, Rozzano, Milan, Italy More articles by this author Lorenzo Tidu Italian Ministry of Defense Military Veterinary Center, Grosseto, Milan, Italy More articles by this author Fabio Grizzi Humanitas Clinical and Research Center, Rozzano, Milan, Italy More articles by this author Valter Torri Istituto di Ricovero e Cura a Carattere Scientifico, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy More articles by this author Alberto Mandressi Humanitas Clinical and Research Center, Rozzano, Milan, Italy More articles by this author Paolo Sardella Italian Ministry of Defense Military Veterinary Center, Grosseto, Milan, Italy More articles by this author Giuseppe La Torre Italian Ministry of Defense Military Veterinary Center, Grosseto, Milan, Italy More articles by this author Giampiero Cocciolone Italian Ministry of Defense Military Veterinary Center, Grosseto, Milan, Italy More articles by this author Mauro Seveso Humanitas Clinical and Research Center, Rozzano, Milan, Italy More articles by this author Guido Giusti Humanitas Clinical and Research Center, Rozzano, Milan, Italy More articles by this author Rodolfo Hurle Humanitas Clinical and Research Center, Rozzano, Milan, Italy More articles by this author Armando Santoro Humanitas Clinical and Research Center, Rozzano, Milan, Italy More articles by this author Pierpaolo Graziotti Humanitas Clinical and Research Center, Rozzano, Milan, Italy More articles by this author Expand All Advertisement PDF downloadLoading ...