Nouvelle voie d'acces au diethylacetal de l'amino-2 cyano-3 formyl-5 pyrazine

Abstract An unequivocal two step synthesis of 2-amino-3-cyano-5-formylpyrazine diethylacetal, starting from dimethylaminoacrolein and O-tosylisonitrosomalononitrile, is described. This pyrazine is a key intermediate for the preparation of folic acid and various analogues.