草酰氯
化学
氯化物
催化作用
羧酸
有机化学
原位
组合化学
作者
Christina Boersch,Eugen Merkul,Thomas J. J. Müller
标识
DOI:10.1002/anie.201103296
摘要
Breaking the bottleneck: α-Keto carboxylic acids and N-heterocyclic carboxylic acids are activated in situ with oxalyl chloride then catalytically alkynylated to give ynediones and N-heterocyclic ynones efficiently in a one-pot fashion. 5-Acylpyrazoles and 2-phenylaminopyrimidines, potentially interesting for pharmaceutical applications, are readily synthesized in concise one-pot, three-component syntheses.
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