Facile synthesis of α-phosphorylated α-amino acids

Various α-phosphorylated α-amino acid derivatives were synthesized conveniently by the reaction of methyl α-methoxyhippurate and methyl α-methoxy-N-benzyloxycarbonyl-glycinate with phosphites under the Lewis acid. Hydrolysis of (12) with TMSI gave 2-phosphonoglycine in quantitative yield.