鞘氨醇
第二信使系统
1-磷酸鞘氨醇
鞘脂
鞘氨醇激酶
脂质信号
信号转导
磷脂酶D
细胞生物学
血小板源性生长因子受体
生物
Gqα亚单位
细胞生长
神经酰胺
血小板衍生生长因子
鞘氨醇激酶1
生长因子
生物化学
受体
G蛋白
细胞凋亡
作者
Ana Olivera,Sarah Spiegel
出处
期刊:Nature
[Springer Nature]
日期:1993-10-01
卷期号:365 (6446): 557-560
被引量:871
摘要
Growth signalling networks that use glycerophospholipid metabolites as second messengers have been well characterized, but less is known of the second messengers derived from sphingolipids, another major class of membrane lipids. A tantalizing link between sphingolipids and cellular proliferation has emerged from the discovery that the sphingolipid metabolites sphingosine and sphingosine-1-phosphate stimulate growth of quiescent Swiss 3T3 fibroblasts by a pathway that is independent of protein kinase C. Sphingosine-1-phosphate is rapidly produced from sphingosine and may mediate its biological effects. Furthermore, sphingosine-1-phosphate triggers the dual signal transduction pathways of calcium mobilization and activation of phospholipase D, prominent events in the control of cellular proliferation. Here we report that activation of sphingosine kinase and the formation of sphingosine-1-phosphate are important in the signal transduction pathways activated by the potent mitogens platelet-derived growth factor (PDGF) and fetal calf serum (FCS).
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