Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1

AimsWe investigated the molecular mechanism underlying the role of transient receptor potential vanilloid type 1 (TRPV1), a Ca2+-permeable non-selective cation channel, in the activation of endothelial nitric oxide (NO) synthase (eNOS) in endothelial cells (ECs) and mice.