致癌物
亚硝基化合物
癌变
癌症
动物研究
生物
化学
亚硝胺
人体研究
生理学
毒理
生物化学
内科学
医学
遗传学
内分泌学
有机化学
作者
Anthony R. Tricker,R. Preußmann
出处
期刊:Mutation research
[Elsevier]
日期:1991-03-01
卷期号:259 (3-4): 277-289
被引量:517
标识
DOI:10.1016/0165-1218(91)90123-4
摘要
Nitrosamines form a large group of genotoxic chemical carcinogens which occur in the human diet and other environmental media, and can be formed endogenously in the human body. N-Nitroso compounds can induce cancer in experimental animals. Some representative compounds of this class induce cancer in at least 40 different animal species including higher primates. Tumours induced in experimental animals resemble their human counterparts with respect to both morphological and biochemical properties. Extensive experimental, and some epidemiological data suggest that humans are susceptible to carcinogenesis by N-nitroso compounds and that the presence of these compounds in some foods may be regarded as an aetiological risk factor for certain human cancers including cancers of the oesophagus, stomach and nasopharynx.
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