病变
医学
磁共振成像
冲程(发动机)
灌注
缺血
磁共振弥散成像
灌注扫描
放射科
脑缺血
核医学
心脏病学
外科
机械工程
工程类
作者
Christian Beaulieu,Alexander de Crespigny,David Tong,Michael E. Moseley,Gregory W. Albers,Michael P. Marks
标识
DOI:10.1002/1531-8249(199910)46:4<568::aid-ana4>3.0.co;2-r
摘要
A prospective longitudinal diffusion-weighted and perfusion-weighted magnetic resonance imaging (DWI/PWI) study of stroke patients (n = 21) at five distinct time points was performed to evaluate lesion evolution and to assess whether DWI and PWI can accurately and objectively demonstrate the degree of ischemia-induced deficits within hours after stroke onset. Patients were scanned first within 7 hours of symptom onset and then subsequently at 3 to 6 hours, 24 to 36 hours, 5 to 7 days, and 30 days after the initial scan. Lesion evolution was dynamic during the first month after stroke. Most patients (18 of 19, 95%) showed increased lesion volume over the first week and then decreased at 1 month relative to 1 week (12 of 14, 86%). Overall, lesion growth appeared to depend on the degree of mismatch between diffusion and perfusion at the initial scan. Abnormal volumes on the acute DWI and PWI (<7 hours) correlated well with initial National Institutes of Health (NIH) stroke scale scores, outcome NIH stroke scale scores, and final lesion volume. DWI and PWI can provide an early measure of metabolic and hemodynamic insufficiency, and thus can improve our understanding of the evolution and outcome after acute ischemic stroke.
科研通智能强力驱动
Strongly Powered by AbleSci AI