Alice T. Shaw,Dong‐Wan Kim,Kazuhiko Nakagawa,Takashi Seto,Lucio Crinó,Myung‐Ju Ahn,Tommaso De Pas,Benjamin Besse,Benjamin Solomon,Fiona Blackhall,Yi−Long Wu,Michael Thomas,Kenneth J. O’Byrne,Denis Moro‐Sibilot,D. Ross Camidge,Tony Mok,Vera Hirsh,Gregory J. Riely,Shrividya Iyer,Vanessa Tassell
In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) have been associated with marked clinical responses to crizotinib, an oral tyrosine kinase inhibitor targeting ALK. Whether crizotinib is superior to standard chemotherapy with respect to efficacy is unknown.
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