ESCRT公司
内体
细胞生物学
胞质分裂
萌芽
转运蛋白
小泡
化学
病毒包膜
TSG101型
生物
膜
生物化学
细胞分裂
微泡
细胞
糖蛋白
基因
细胞内
小RNA
作者
Suman Lata,Guy Schoehn,Julianna Solomons,Ricardo S. Vieira-Pires,Heinrich G. Göttlinger,Winfríed Weissenhorn
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2009-01-20
卷期号:37 (1): 156-160
被引量:67
摘要
ESCRT-III (endosomal sorting complex required for transport III) is required for the formation and abscission of intraluminal endosomal vesicles, which gives rise to multivesicular bodies, budding of some enveloped viruses and cytokinesis. ESCRT-III is composed of 11 members in humans, which, except for one, correspond to the six ESCRT-III-like proteins in yeast. At least CHMP (charged multivesicular body protein) 2A and CHMP3 assemble into helical tubular structures that provide a platform for membrane interaction and VPS (vacuolar protein sorting) 4-catalysed effects leading to disassembly of ESCRT-III CHMP2A–CHMP3 polymers in vitro. Progress towards the understanding of the structures and function of ESCRT-III, its activation, its regulation by accessory factors and its role in abscission of membrane enveloped structures in concert with VPS4 are discussed.
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