线粒体
线粒体DNA
癌症
生物
计算生物学
功能(生物学)
癌细胞
遗传学
生物信息学
癌症研究
基因
作者
Josephine S. Modica-Napolitano,Keshav K. Singh
出处
期刊:Mitochondrion
[Elsevier]
日期:2004-09-01
卷期号:4 (5-6): 755-762
被引量:273
标识
DOI:10.1016/j.mito.2004.07.027
摘要
Nearly a century of scientific research has revealed a number of notable differences in the structure and function of mitochondria between normal and cancer cells, including differences in metabolic activity, molecular composition, and mtDNA sequence. This article reviews several of these differences and discusses their clinical implications, especially with regard to the use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents.
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