均质机
材料科学
聚乙烯醇
聚合物
生物降解
微球
可生物降解聚合物
乳状液
化学工程
复合材料
色谱法
有机化学
化学
工程类
作者
Kai Guo,Chih‐Chang Chu
摘要
Abstract Novel biodegradable submicron microspheres of amino acid based poly(ester amide)s (PEAs) were fabricated by an oil‐in‐water (O/W) emulsion/solvent evaporation technique and their morphology and drug loading efficiency were examined. PEAs microspheres of mean diameter <1 μm with very narrow size distribution were obtained at a fair yield about 80%. The effects of PEA polymer concentration, polyvinyl alcohol emulsifier concentration, and the homogenizer speed on the size and morphology of final PEA microspheres were examined by analyzing their SEM images. It is found that a low PEA concentration, a high PVA concentration, and a high homogenizer speed are the optimal conditions for obtaining smaller microspheres. The biodegradation behaviors of these PEA microspheres at 37°C were investigated as a function of enzyme (α‐chymotrypsin) concentration and incubation time. The data showed similar surface erosion degradation mechanism as PEA polymers reported previously. Paclitaxel loaded PEA microspheres with high encapsulation efficiency were obtained without significantly affecting their size and surface morphology. The high drug loading efficiency close to 100% suggested that PEA microspheres may have the potential for the injection administration of highly hydrophobic anticancer drugs. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
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