细胞因子
癌症
免疫
功能(生物学)
免疫学
疾病
生物
发病机制
免疫系统
医学
细胞生物学
遗传学
病理
作者
Mark H. Mannino,Ziwen Zhu,Hualiang Xiao,Qian Bai,Mark R. Wakefield,Yujiang Fang
出处
期刊:Cancer Letters
[Elsevier]
日期:2015-10-01
卷期号:367 (2): 103-107
被引量:353
标识
DOI:10.1016/j.canlet.2015.07.009
摘要
Interleukin-10 (IL-10) produced by a wide-variety of cells is a highly pleiotropic cytokine. It has been implicated in the pathogenesis and/or development of autoimmune diseases and cancer, although it displays differential effects that seem to be contradictory sometimes. The ultimate role of this cytokine in disease, however, cannot be fully determined until the immunological contexts that regulate its function are further elucidated. In this review, we will discuss a wide variety of evidence of IL-10 in immunity and cancer in an effort to illuminate the remaining mysteries in the function of this cytokine that, when fully understood, may prove to be a powerful tool in the battle against cancer.
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