亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

The effect of Diprivan (propofol) on phosphorylcholine surfaces during cardiopulmonary bypass — an in vitro investigation

异丙酚 医学 体外循环 体外循环 麻醉 氧合器 体外 生理盐水 芬太尼 麻醉剂 药理学 红细胞压积 磷酰胆碱 色谱法 外科 化学 生物化学 内分泌学
作者
Gerard J. Myers,Cheri Voorhees,Bob Eke,RenRen Johnstone
出处
期刊:Perfusion [SAGE]
卷期号:24 (5): 349-355 被引量:30
标识
DOI:10.1177/0267659109353819
摘要

It is well known that extracorporeal surfaces have the ability to bind such drugs as fentanyl, nitroglycerine and propofol. Adsorption of the injectable anesthetic agent Diprivan (propofol) onto uncoated and heparin-coated extracorporeal surfaces during cardiopulmonary bypass (CPB) has been previously investigated; however, propofol adsorption onto synthetic-coated extracorporeal surfaces has not been published previously. The focus of this investigation was on the interaction of propofol and the synthetic biomimetic coating from the Sorin Group called Mimesys (phosphorylcholine (PC)). A randomized series of six in vitro experiments were done with propofol using both PC-coated circuits without arterial filters and those with arterial filters. The circuits were identical in all experiments and priming remained the same, with 750 mls of normal saline and 1250 mls of fresh bovine blood (hematocrit 41.0 +/- 1.0%). After circulation and collection of baseline samples, the first (low) dose of 4 mg (4000 mcg) of Diprivan 1% was added to the perfusate, followed by the second (high) dose of 40 mg (40,000 mcg) and the final challenge (extreme dose) of 356 mg (356,000 mcg) of Diprivan. Drug assay was done by an independent laboratory, using the standardized method of High Performance Liquid Chromatography (HPLC). Measurements of total propofol were done at baseline, 20 minutes, 40 minutes and 60 minutes after each injection. Oxygenator performance was also measured prior to the addition of propofol and repeated after exposure to 4 mg, 40mg and 356 mg propofol for 60 min, 120 min and 180 minutes of circulation. Results indicate that phosphorylcholine coating does not prevent the adsorption of propofol during extracorporeal circulation and the oxygenator's gas exchange ability is not affected by prolonged exposure to an extreme dose of the medication during high flow extracorporeal circulation.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
13654135090完成签到,获得积分10
1秒前
123发布了新的文献求助10
4秒前
beloved完成签到 ,获得积分10
7秒前
lingkai完成签到 ,获得积分10
17秒前
WLL发布了新的文献求助10
28秒前
中西西完成签到 ,获得积分10
32秒前
37秒前
WLL完成签到,获得积分20
44秒前
53秒前
1分钟前
积极的尔白完成签到 ,获得积分10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
Owen应助科研通管家采纳,获得10
1分钟前
1分钟前
jnrr完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
关关发布了新的文献求助10
1分钟前
Jinyang完成签到 ,获得积分10
1分钟前
2分钟前
2分钟前
传奇3应助whoami采纳,获得10
2分钟前
mmmmm发布了新的文献求助10
2分钟前
可夫司机完成签到 ,获得积分10
2分钟前
docyuchi发布了新的文献求助10
2分钟前
2分钟前
划落落发布了新的文献求助20
2分钟前
2分钟前
隋嫣然完成签到,获得积分10
2分钟前
酷波er应助Swii采纳,获得10
2分钟前
2分钟前
2分钟前
青阳发布了新的文献求助30
3分钟前
小马甲应助科研通管家采纳,获得10
3分钟前
青阳完成签到,获得积分10
3分钟前
科目三应助划落落采纳,获得10
3分钟前
以菱完成签到 ,获得积分10
3分钟前
3分钟前
ff完成签到,获得积分10
3分钟前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3252956
求助须知:如何正确求助?哪些是违规求助? 2895494
关于积分的说明 8286877
捐赠科研通 2564312
什么是DOI,文献DOI怎么找? 1392288
科研通“疑难数据库(出版商)”最低求助积分说明 652110
邀请新用户注册赠送积分活动 629387