干细胞
癌症干细胞
造血
生物
癌症研究
癌变
癌症
干细胞衰老理论
细胞生物学
祖细胞
诱导干细胞
癌细胞
成体干细胞
内皮干细胞
遗传学
干细胞因子
体外
作者
Tannishtha Reya,Sean J. Morrison,Michael F. Clarke,Irving L. Weissman
出处
期刊:Nature
[Springer Nature]
日期:2001-11-01
卷期号:414 (6859): 105-111
被引量:9406
摘要
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells' — rare cells with indefinite potential for self-renewal that drive tumorigenesis.
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