神经科学
光遗传学
中间神经元
基底外侧杏仁核
帕尔瓦布明
扁桃形结构
联想学习
心理学
恐惧条件反射
神经可塑性
大脑中的恐惧处理
生物神经网络
抑制性突触后电位
生物
作者
Steffen B. E. Wolff,Jan Gründemann,Philip Tovote,Sabine Krabbe,Gilad A. Jacobson,Christian Müller,Cyril Herry,Ingrid Ehrlich,Rainer W. Friedrich,Johannes J. Letzkus,Andreas Lüthi
出处
期刊:Nature
[Springer Nature]
日期:2014-05-09
卷期号:509 (7501): 453-458
被引量:470
摘要
Learning is mediated by experience-dependent plasticity in neuronal circuits. Activity in neuronal circuits is tightly regulated by different subtypes of inhibitory interneurons, yet their role in learning is poorly understood. Using a combination of in vivo single-unit recordings and optogenetic manipulations, we show that in the mouse basolateral amygdala, interneurons expressing parvalbumin (PV) and somatostatin (SOM) bidirectionally control the acquisition of fear conditioning--a simple form of associative learning--through two distinct disinhibitory mechanisms. During an auditory cue, PV(+) interneurons are excited and indirectly disinhibit the dendrites of basolateral amygdala principal neurons via SOM(+) interneurons, thereby enhancing auditory responses and promoting cue-shock associations. During an aversive footshock, however, both PV(+) and SOM(+) interneurons are inhibited, which boosts postsynaptic footshock responses and gates learning. These results demonstrate that associative learning is dynamically regulated by the stimulus-specific activation of distinct disinhibitory microcircuits through precise interactions between different subtypes of local interneurons.
科研通智能强力驱动
Strongly Powered by AbleSci AI