Ribosomal RNA Genes, RNA Polymerases, Nucleolar Structures, and Synthesis of rRNA in the Yeast Saccharomyces cerevisiae

When the structural complexity of ribosomes becameevident in the early 1960s, two obvious questions wereasked. The first concerns how the large and small rRNAs,as well as many ribosomal protein molecules, are organized within ribosomal particles and how the ribosomemachine makes proteins; that is, the question of structureand function. The second question is how these molecular components are synthesized and then assembled intosuch complex and yet specific structures, and how suchsynthetic processes are regulated; that is, the question ofbiosynthesis and its regulation...