狼疮性肾炎
医学
尼福林
TLR9型
抗dsDNA抗体
足细胞
免疫学
系统性红斑狼疮
波多辛
肾
病理
内科学
蛋白尿
生物
基因表达
遗传学
疾病
DNA甲基化
基因
作者
Haruhiko Machida,Shuichi Ito,Tomonori Hirose,Fumihiko Takeshita,Hisashi Oshiro,Tomoko Nakamura,Masaaki Mori,Yoshiaki Inayama,Yan Kou,Naoto Kobayashi,Shumpei Yokota
摘要
Background. Childhood-onset systemic lupus erythematosus (SLE) is frequently complicated with lupus nephritis (LN), which is characterized by the deposition of DNA-containing immune complex to the glomerulus. Toll-like receptor 9 (TLR9), capable of recognizing the microbially derived CpG oligonucleotide, plays a crucial role in the innate immunity. TLR9 is also assumed to be related to the aetiology of SLE in the recognition of anti-DNA antibody-containing immune complex, but this remains controversial. We conducted a study to elucidate the association between TLR9 and LN in childhood-onset SLE.
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