微生物学
免疫系统
生物
CD80
抗原
CD86
巨噬细胞
CD40
体内
肿瘤坏死因子α
免疫学
抗体
体外
T细胞
细胞毒性T细胞
生物化学
生物技术
作者
Jia Tong,Qingzhen Han,Shengjun Wang,Zhaoliang Su,Zheng Dong,Pei Shen,Sheng Xia,Xinxiang Huang,Qixiang Shao,Huaxi Xu
标识
DOI:10.1258/ebm.2012.012181
摘要
Corynebacterium pyruviciproducens is a newly discovered Corynebacterium species with no known pathogenic components such as diphtheria toxin and tuberculostearic acid, and it has similar biological properties to Propionibacterium acnes, but its role of immunoregulation is drawing people's attention. In this work, based on the role of macrophages in removal of pathogenic bacteria as a primary scavenger and particulate antigen-presenting cell, the stimulation of macrophages by C. pyruviciproducens was analyzed through detecting the levels of cytokine secretion and expression of membrane molecules, and the effect of C. pyruviciproducens in promoting antibody response to sheep red blood cells (SRBC) in vivo was detected. In vitro, C. pyruviciproducens led to a sharp release of interleukin-6 and tumour necrosis factor-α and encouraged the activation of macrophages including enhanced expressions of MHC-II, CD40, CD80 and CD86. In vivo, it enhanced the humoral immune response against SRBC, a particulate antigen. These observations suggest that C. pyruviciproducens, as an immunoregulator, can promote the host humoral immune response to pathogenic microorganisms by regulating macrophage function.
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