CTLA-4号机组
T细胞
受体
免疫学
生物
抗体
医学
细胞生物学
免疫系统
化学
癌症研究
内科学
作者
Paul Waterhouse,Josef Penninger,Emma Timms,Andrew Wakeham,Arda Shahinian,Kelvin P. Lee,Craig B. Thompson,Henrik Griesser,Tak W. Mak
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1995-11-10
卷期号:270 (5238): 985-988
被引量:2707
标识
DOI:10.1126/science.270.5238.985
摘要
The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been controversial. Here, lymph nodes and spleens of CTLA-4-deficient mice accumulated T cell blasts with up-regulated activation markers. These blast cells also infiltrated liver, heart, lung, and pancreas tissue, and amounts of serum immunoglobulin were elevated. The mice invariably became moribund by 3 to 4 weeks of age. Although CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation. Thus, CTLA-4 acts as a negative regulator of T cell activation and is vital for the control of lymphocyte homeostasis.
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