NAD+激酶
烟酰胺磷酸核糖转移酶
CD38
烟酰胺腺嘌呤二核苷酸
锡尔图因
生物
西妥因1
辅因子
生物化学
SIRT3
酶
细胞生物学
川地34
干细胞
基因
下调和上调
作者
Shin‐ichiro Imai,Leonard Guarente
标识
DOI:10.1016/j.tcb.2014.04.002
摘要
Nicotinamide adenine dinucleotide (NAD+) is a classical coenzyme mediating many redox reactions. NAD+ also plays an important role in the regulation of NAD+-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD+ biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. NAD+ levels decline during the aging process and may be an Achilles' heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies. Restoring NAD+ by supplementing NAD+ intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases. Thus, the combination of sirtuin activation and NAD+ intermediate supplementation may be an effective antiaging intervention, providing hope to aging societies worldwide.
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