核酸
小分子
核酸结构
化学
分子
构象变化
生物化学
生物物理学
计算生物学
生物
核糖核酸
基因
有机化学
作者
Linus Pauling,J. H. Sturdivant
标识
DOI:10.1073/pnas.23.12.615
摘要
Fast, low-cost, accurate detection of time-resolved dynamic nucleic acid conformational variation in response to small molecule binding: 1) enriches our understanding of nucleic acid structure, and regulation of structure by small molecules as ...Nucleic acids can undergo conformational changes upon binding small molecules. These conformational changes can be exploited to develop new therapeutic strategies through control of gene expression or triggering of cellular responses and can also be used ...
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