间质细胞
CCL19型
白浆
细胞生物学
生物
B细胞
边缘地带
分区(防火)
趋化因子
成纤维细胞
脾脏
免疫学
分子生物学
细胞培养
癌症研究
炎症
抗体
趋化因子受体
遗传学
酶
生物化学
作者
Karin Schaeuble,Mirjam R. Britschgi,Leo Scarpellino,Stéphanie Favre,Ying Xu,Ekaterina P. Koroleva,Tonje Katrine A. Lissandrin,Alexander Link,Mehrdad Matloubian,Carl F. Ware,Sergei A. Nedospasov,Alexei V. Tumanov,Jason G. Cyster,Sanjiv A. Luther
出处
期刊:Cell Reports
[Cell Press]
日期:2017-11-01
卷期号:21 (9): 2500-2514
被引量:29
标识
DOI:10.1016/j.celrep.2017.10.119
摘要
T and B cell compartmentalization is a hallmark of secondary lymphoid organs and is maintained by chemokine-expressing stromal cells. How this stromal cell network initially develops and differentiates into two distinct subsets is poorly known, especially for the splenic white pulp (WP). Here, we show that perivascular fibroblast precursors are triggered by LTα1β2 signals to expand, express CCL19/21, and then differentiate into two functionally distinct fibroblast subsets responsible for B and T cell clustering and WP compartmentalization. Failure to express or sense CCL19 leads to impaired T zone development, while lack of B cells or LTα1β2 leads to an earlier and stronger impairment in WP development. We therefore propose that WP development proceeds in multiple steps, with LTα1β2+ B cells acting as major inducer cells driving the expansion and gradual differentiation of perivascular fibroblasts into T and B zone organizer cells.
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