小胶质细胞
神经科学
免疫系统
功能(生物学)
平衡
生物
中枢神经系统
神经胶质
免疫学
细胞生物学
炎症
作者
Katrin Kierdorf,Marco Prinz
摘要
Microglial cells are the resident tissue macrophages of the CNS and are widely recognized for their immune surveillance of the healthy CNS. In addition to this well-accepted function, recent findings point to major roles for microglia in instructing and regulating the proper function of the neuronal networks in the adult CNS, but these cells are also involved in creating neuronal networks by orchestrating construction of the whole network during development. In this Review, we highlight recent findings about the steady-state functions of microglial cells, the factors that are important for physiological microglial function, and how microglia help to maintain tissue homeostasis in the CNS.
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