失调
溃疡性结肠炎
发病机制
免疫学
免疫系统
肠道菌群
肠粘膜
炎症性肠病
移植
内科学
势垒函数
丁酸盐
生物
医学
疾病
发酵
细胞生物学
食品科学
作者
Zhaohua Shen,Changxin Zhu,Yongsheng Quan,Zhenyu Yang,Shuai Wu,Weiwei Luo,Bei Tan,Xiaoyan Wang
摘要
Ulcerative colitis (UC) is an inflammatory disease that mainly affects the colon and rectum.It is believed that genetic factors, host immune system disorders, intestinal microbiota dysbiosis, and environmental factors contribute to the pathogenesis of UC. however, studies on the role of intestinal microbiota in the pathogenesis of UC have been inconclusive.Studies have shown that probiotics improve intestinal mucosa barrier function and immune system function and promote secretion of anti-inflammatory factors, thereby inhibiting the growth of harmful bacteria in the intestine.Fecal microbiota transplantation (FMT) can reduce bowel permeability and thus the severity of disease by increasing the production of short-chain fatty acids, especially butyrate, which help maintain the integrity of the epithelial barrier.FMT can also restore immune dysbiosis by inhibiting Th1 differentiation, activity of T cells, leukocyte adhesion, and production of inflammatory factors.Probiotics and FMT are being increasingly used to treat UC, but their use is controversial because of uncertain efficacy.Here, we briefly review the role of intestinal microbiota in the REVIEW
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