微生物群
扩增子测序
人类微生物组计划
人体微生物群
计算生物学
基因组
生物
基因组
DNA测序
人类基因组
放大器
人类疾病
人类健康
数据科学
核糖体RNA
生物信息学
遗传学
基因
16S核糖体RNA
计算机科学
医学
聚合酶链反应
环境卫生
作者
Julie Segre,Katie Pollard
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2017-09-29
卷期号:357 (6358): 1425-1425
标识
DOI:10.1126/science.357.6358.1425-b
摘要
Our knowledge of the role of the human microbiome in health and disease has been growing in recent years, but analysis of the microbiome—such as amplicon sequencing of the highly conserved 16S ribosomal RNA (rRNA) gene—has proved challenging. Thanks to the rapidly declining costs of next-generation sequencing, whole-genome microbial sequencing is now emerging as a viable alternative for disease research, providing a more detailed analysis of the species present in the microbiome. Together with our invited experts, we will explore how this shift is changing the way researchers are approaching microbiome analysis, and what the additional information obtained can tell us about how the health of the microbiome impacts human health and well-being.
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