孟德尔遗传
遗传学
生物
疾病
遗传建筑学
基因
人口
人类遗传学
全基因组关联研究
鉴定(生物学)
复杂疾病
进化生物学
表型
医学
基因型
单核苷酸多态性
生态学
环境卫生
病理
作者
Glenys Thomson,Michael S. Esposito
标识
DOI:10.1016/s0968-0004(99)01499-1
摘要
Genetic factors influence virtually every human disorder, determining disease susceptibility or resistance and interactions with environmental factors. Our recent successes in the genetic mapping and identification of the molecular basis of mendelian traits have been remarkable. Now, attention is rapidly shifting to more-complex, and more-prevalent, genetic disorders and traits that involve multiple genes and environmental effects, such as cardiovascular disease, diabetes, rheumatoid arthritis and schizophrenia. Rather than being due to specific and relatively rare mutations, complex diseases and traits result principally from genetic variation that is relatively common in the general population. Unfortunately, despite extensive efforts by many groups, only a few genetic regions and genes involved in complex diseases have been identified. Completion of the human genome sequence will be a seminal accomplishment, but it will not provide an immediate solution to the genetics of complex traits.
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