医学
药物发现
药理学
药品
加药
药效学
药代动力学
临床药理学
试验药物
体内
药物开发
计算生物学
疾病
临床试验
生物信息学
生物
内科学
生物技术
作者
Sherri Dudal,Caterina Bissantz,Antonello Caruso,Pascale David‐Pierson,Wouter H. P. Driessen,Erich Koller,Ben‐Fillippo Krippendorff,Martin Lechmann,Andrés Olivares‐Morales,Axel Paehler,Caroline Rynn,D. Türck,Arthur J. Van De Vyver,Ken Wang,Lotte Winther
标识
DOI:10.1016/j.drudis.2022.03.009
摘要
Many in vitro and in vivo models are used in pharmacological research to evaluate the role of targeted proteins in a disease. Understanding the translational relevance and limitation of these models for analyzing a drug's disposition, pharmacokinetic/pharmacodynamic (PK/PD) profile, mechanism, and efficacy, is essential when selecting the most appropriate model of the disease of interest and predicting clinically efficacious doses of the investigational drug. Selected animal models used in ophthalmology, infectious diseases, oncology, autoimmune diseases, and neuroscience are reviewed here. Each area has specific challenges around translatability and determination of an efficacious dose: new patient-specific dosing methods may help overcome these limitations.
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