自噬
转录组
细胞生物学
细胞内
平衡
生物
蛋白质组
细胞器
神经科学
生物信息学
细胞凋亡
基因表达
基因
生物化学
作者
Vijay Arruri,Raghu Vemuganti
标识
DOI:10.1016/j.expneurol.2022.114032
摘要
Autophagy is an evolutionarily conserved intracellular system that routes distinct cytoplasmic cargo to lysosomes for degradation and recycling. Accumulating evidence highlight the mechanisms of autophagy, such as clearance of proteins, carbohydrates, lipids and damaged organelles. The critical role of autophagy in selective degradation of the transcriptome is still emerging and could shape the total proteome of the cell, and thus can regulate the homeostasis under stressful conditions. Unregulated autophagy that potentiates secondary brain damage is a key pathological features of acute CNS injuries such as stroke and traumatic brain injury. This review discussed the mutual modulation of autophagy and RNA and its significance in mediating the functional consequences of acute CNS injuries.
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