神经科学
缝隙连接
连接蛋白
星形胶质细胞
突触可塑性
长时程增强
生物
海马结构
神经传递
兴奋性突触后电位
变质塑性
神经可塑性
小胶质细胞
生物神经网络
细胞内
细胞生物学
中枢神经系统
抑制性突触后电位
免疫学
受体
炎症
生物化学
作者
Ladina Hösli,Noemi Binini,Kim David Ferrari,Laetitia Thieren,Zoe J. Looser,Marc Zuend,Henri S. Zanker,Stewart Berry,Martin Holub,Wiebke Möbius,Torben Ruhwedel,Klaus‐Armin Nave,Christian Giaume,Bruno Weber,Aiman S. Saab
出处
期刊:Cell Reports
[Elsevier]
日期:2022-03-01
卷期号:38 (10): 110484-110484
被引量:67
标识
DOI:10.1016/j.celrep.2022.110484
摘要
The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and memory are still poorly explored. Astrocytes form large intercellular networks by gap junction coupling, mainly composed of two gap junction channel proteins, connexin 30 (Cx30) and connexin 43 (Cx43). To circumvent developmental perturbations and to test whether astrocytic gap junction coupling is required for hippocampal neural circuit function and behavior, we generate and study inducible, astrocyte-specific Cx30 and Cx43 double knockouts. Surprisingly, disrupting astrocytic coupling in adult mice results in broad activation of astrocytes and microglia, without obvious signs of pathology. We show that hippocampal CA1 neuron excitability, excitatory synaptic transmission, and long-term potentiation are significantly affected. Moreover, behavioral inspection reveals deficits in sensorimotor performance and a complete lack of spatial learning and memory. Together, our findings establish that astrocytic connexins and an intact astroglial network in the adult brain are vital for neural homeostasis, plasticity, and spatial cognition.
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