原位
微流控
平版印刷术
俘获
材料科学
投影(关系代数)
粒子(生态学)
数字光处理
纳米技术
光学镊子
无光罩微影
数字微镜装置
软光刻
计算机科学
化学
光电子学
光学
人工智能
抵抗
电子束光刻
物理
制作
替代医学
投影机
图层(电子)
地质学
有机化学
病理
海洋学
生物
医学
生态学
算法
作者
Han Zhang,Meiying Lu,Zheng Xiong,Jing Yang,Mingyue Tan,Long Huang,Xiaojuan Zhu,Zifeng Lu,Yang Yang,Hua Liu
出处
期刊:Lab on a Chip
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:22 (10): 1951-1961
被引量:7
摘要
Real-time and fast trapping and tagging of microfeatures, such as microparticles and cells, are of great significance for biomedical research. In this work, we propose a novel in situ digital projection lithography technology that integrates real-time, in situ generation of digital masks for particle processing and fluid control into conventional DMD-based projection lithography. With the help of image recognition technology, we rapidly resolve the information of the microparticle profile or channel location, combining the selection of existing masks of different shapes, thus enabling in situ generation of user-customized micro-trap arrays and microfilter arrays for particle trapping and tagging. The success in trapping and filtering single particles, particle arrays, and cells has indicated the promising prospects of this novel technology for broad applications in microfluidics, single-cell analysis, and early-stage disease diagnostics.
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