汤剂
毒性
医学
体内
急性毒性
药理学
脾脏
肺
肾
血液学
中医药
传统医学
生理学
内科学
病理
生物
生物技术
替代医学
作者
Qing Wang,Liming Zhao,Hui Zhang,Shuo Zhang,Yang Pu,Huanhuan Wang,Qingyan Yuan,Guanlian Wu,Chunli Wu
标识
DOI:10.1016/j.jep.2021.114940
摘要
Sanren decoction (SRD) is a well-known traditional Chinese medicine prescription containing eight kinds of materials. SRD has been used mainly in China for more than 200 years for the treatment of respiratory disorders that co-occur with a bad fever after midday.To evaluate the acute and 28-day subacute toxicity of an aqueous extract of SRD using in vivo methods.To determine acute toxicity, SRD was administered by gavage at a dosage of 58.5 g/kg/day to male and female mice for 7 days. To determine subacute toxicity, SRD was administered at 3.3, 6.5, or 13 g/kg/day to male and female rats for 28 days. The general behavior, body weight, biochemical and hematological parameters, organ coefficients and pathological morphology of the treated animals were analyzed.Neither acute nor subacute concentrations of SRD caused significant changes in the body weights, general behavior, hematology and biochemical parameters, organ weights, or histopathological appearances of the liver, kidney, spleen, brain, lung or heart in mice or rats.The administration of SRD can be considered safe within the conditions of this study.
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