In Reply The focus of our recent article 1 was on clinical decision-making surrounding results of APOE allele testing.Although outside the scope of the original article and this response, in our view, the inference of a label of mild cognitive impairment-solely based on a score on an office screening assessment without regard for other data (including but not limited to normal and stable serial clinical evaluations and neuropsychological testing as described in the article)-is also not warranted.The brief vignette describes pertinent history and examination data and otherwise notes the patient as "generally healthy," which we intended to succinctly reflect that the cardinal features of depression were queried, and all were absent except for the cognitive concerns.Although we agree that a psychiatric consultation is reasonable if depression is suspected as a cause or contributor to cognitive concerns, this was not viewed as warranted in this patient.