Molecular recognition-driven supramolecular nanoassembly of a hydrophobic uracil prodrug and hydrophilic cytarabine for precise combination treatment of solid and non-solid tumors

The reduction sensitive supramolecular nanoassembly was based on U-SS-DOX and Ara-C specific molecular recognition. The drug release in the supramolecular nanoassembly was triggered and controlled in tumor cells with low pH and excessive GSH.