Turn‐on luminescent sensing of glutathione and cysteine based on post‐modified Bio‐MOF‐1

Abstract Glutathione (GSH) and cysteine (Cys) play important roles in many neurological diseases. Therefore, it is very significant to design and synthesis new type GSH and Cys probes. The Cu 2+ ion was incorporated into Bio‐MOF‐1 to synthesize Cu 2+ @Bio‐MOF‐1 through postsynthetic modification. GSH and Cys show strong affinity for Cu 2+ ion, so the Cu 2+ @Bio‐MOF‐1 exhibits highly sensitive turn‐on sensing of GSH and Cys. Furthermore, the limit of detection (LOD) of Cu 2+ @Bio‐MOF‐1 for the sensing of GSH and Cys was estimated to be 12.4 and 56 μM, hence, Cu 2+ @Bio‐MOF‐1 has promising application potential for determination of GSH and Cys.