血管生成
疾病
医学
药理学
体内
他汀类
糖尿病
HMG-CoA还原酶
癌症
胆固醇
生物信息学
癌症研究
酶
生物
还原酶
内科学
内分泌学
生物化学
生物技术
作者
Fatemeh Zahedipour,Alexandra E. Butler,Manfredi Rizzo,Amirhossein Sahebkar
标识
DOI:10.1016/j.drudis.2022.07.005
摘要
Statins inhibit HMG-CoA reductase by competitively inhibiting the active site of the enzyme, thus preventing cholesterol synthesis and reducing the risk of developing cardiovascular disease. Many pleiotropic effects of statins have been demonstrated that can be either related or unrelated to their cholesterol-lowering ability. Among these effects are their proangiogenic and antiangiogenic properties that could offer new therapeutic applications. In this regard, pro- and anti-angiogenic properties of statins have been shown to be dose dependent. Statins also appear to have a variety of non-cardiovascular angiogenic effects in many diseases, some examples being ocular disease, brain disease, cancer, preeclampsia, diabetes and bone disease, which are discussed in this review using reports from in vitro and in vivo investigations.
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