石墨烯
姜黄素
纳米材料
抗菌活性
氧化物
光敏剂
抗菌剂
化学
生物相容性
金黄色葡萄球菌
光动力疗法
材料科学
纳米技术
光化学
有机化学
细菌
生物化学
生物
遗传学
作者
Hongjun Yan,Peiyuan Li,Xiantao Jiang,Xiaoxun Wang,Yuting Hu,Ying Zhang,Rixiang Su,Wei Su
出处
期刊:Biomaterials advances
日期:2022-08-01
卷期号:139: 213040-213040
被引量:21
标识
DOI:10.1016/j.bioadv.2022.213040
摘要
Curcumin (Cur) plays a key role in photodynamic antibacterial activity as a photosensitizer. On the other hand, the antimicrobial potential of graphene oxide (GO) has been reported controversially, and how to improve its antimicrobial ability has become an meaningful study. In this study, we prepared polydopamine-curcumin (PDA-Cur) by pi-pi stacking and loaded it onto the GO surface to obtain GO/PDA-Cur composite nanomaterials. GO/PDA-Cur was characterized by physical and optical means, and GO/PDA-Cur possessed good dispersion and stability in water. In vitro antibacterial results showed that GO/PDA-Cur mediated photodynamic therapy significantly reduced Gram-positive Staphylococcus aureus (S. aureus) by 4 orders of magnitude with a bactericidal rate of 99.99 %. The antibacterial mechanism stems from the fact that GO/PDA-Cur can generate reactive oxygen species (ROS) under white light irradiation (405–780 nm), which causes bacterial outer membrane breakage and cellular deformation. In addition, GO/PDA-Cur has good biocompatibility. The antibacterial ability of graphene oxide was significantly improved by combining it with PDA-Cur, which allows it to be used as a photodynamic antibacterial material.
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