Synthesis of Bis(indolyl)methane/Dihydropyrimidinone Tethered Bis‐Amidic Triazole Hybrid Compounds via One‐Pot Sequential Six/Seven Component Ugi‐Click Reaction

Abstract Synthesis of bis(indolyl)methane/dihydropyrimidinone based bis‐amide‐triazole hybrid compounds has been achieved via one‐pot six/seven‐component sequential Ugi‐Click reaction. Two molecular libraries of anti‐bacterial compounds containing significant pharmacophoric nuclei were synthesized in good yield and purity using green solvent, mild reaction conditions with atom economy by structural modifications in three independent starting materials.