流动化学
放大
化学
光化学
比例(比率)
流量(数学)
转化(遗传学)
连续流动
过程(计算)
组合化学
产品(数学)
工艺工程
生物系统
计算化学
生化工程
计算机科学
数学
机械
物理
经典力学
工程类
生物化学
操作系统
基因
几何学
生物
量子力学
作者
Robbie Radjagobalou,Miguel Imbratta,Julie Bergraser,Marion Gaudeau,Gildas Lyvinec,Dominique Delbrayelle,Olivier Jentzer,Jérémy Roudin,Benjamin Laroche,Stéphanie Ognier,Michaël Tatoulian,Janine Cossy,Pierre‐Georges Echeverria
标识
DOI:10.1021/acs.oprd.2c00065
摘要
A selective photochemical monochlorination of 2-fluorotoluene has been developed by a continuous flow process using two different flow reactors, one for the tuning of the conditions and the second one for the scale-up. The key reaction parameters were optimized using one-factor-at-a-time and design of experiment methods, with the goal of minimizing the formation of the dichlorinated by-product. This transformation has been performed on a multi decagram scale.
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