Mycoplasma pneumoniae is the most common cause of community-acquired pneumonia in children. Macrolide has been used as the first-line treatment of mycoplasma pneumonia, but in the 2000s macrolide-resistant and 2nd-line treatment needed mycoplasma pneumonia has been increasing. We aimed to investigate the predictive factor of macrolide-resistant mycoplasma pneumonia for analyzing blood inflammatory biomarkers.