Temperature sensitive polyMOF hydrogel formed by in situ open-ring polymerization for infected chronic wound treatment

原位 开环聚合 聚合 原位聚合 材料科学 高分子化学 戒指(化学) 慢性伤口 化学 自愈水凝胶 伤口愈合 生物医学工程 化学工程 复合材料 外科 聚合物 医学 有机化学 工程类
作者
Wei Nie,Yixiong Huang,Yilin Wang,Carlos Kengla,Joshua Copus,Jielin Sun,Zhifeng Shao,Xinyi Dai,Yi Shen
出处
期刊:Chemical Engineering Journal [Elsevier BV]
卷期号:446: 136948-136948 被引量:23
标识
DOI:10.1016/j.cej.2022.136948
摘要

• The polyMOF (CuPP-PELA) composite was prepared by in situ ROP reaction first time. • The in situ formed PELA could accelerate the degradation of MOF (CuPP). • The burst release of Curcumin under NIR sensitize the photothermal sterilization. • Curcumin gradually released without NIR remodulate the immune microenvironment. Chronic wounds, especially those caused by drug-resistant bacteria, remain mostly intractable to existing treatments. Photothermal therapy, apart from the additional inflammation it may cause, exhibits potent ability to efficiently destroy drug-resistant bacteria. A system capable of thermal therapy together with active regulation of the repairing process could be a potentially effective treatment for these wounds. Here we developed a highly integrated hydrogel made of curcumin loaded copper-tetrakis(4-carboxyphenyl)porphyrin metal–organic framework and poly (ethylene glycol)-poly(ε-caprolactone-co-lactide) hybrid by in situ ring-opening polymerization. It combines photothermal effect, immune modulatory, hemostasis and temperature-sensitive sol–gel transition capacity. This multifunctional polymer-metal–organic framework (polyMOF) hydrogel dressing showed the ability to completely heal drug-resistant bacteria infected wounds within 14 days and could be an effective and biocompatible material for chemo-photothermal therapy against chronic wounds. Moreover, our strategy to prepare the polyMOF hybrid may provide a universal approach for the development of multifunctional gels with great significance in clinical application.
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