抗坏血酸
石墨烯
检出限
电化学气体传感器
微分脉冲伏安法
循环伏安法
共价键
介电谱
化学
钴
电化学
无机化学
分析化学(期刊)
材料科学
核化学
电极
纳米技术
有机化学
色谱法
物理化学
食品科学
作者
Charles Luhana,Iphithuli Moyo,Keamogetse Tshenkeng,Philani Mashazi
标识
DOI:10.1016/j.microc.2022.107605
摘要
Here, we constructed an electrochemical sensor for the detection of catecholamine neurotransmitters based on covalent composite of cobalt tetra-(3-carboxyphenoxy) phthalocyanine (CoTCPhOPc) onto aminated graphene quantum dots (AmGQDs). The electrochemical behaviour of the covalent composite modified gold surface was studied using cyclic voltammetry, differential pulse voltammetry, square wave voltammetry and electrochemical impedance spectroscopy. The electrochemical sensor fabricated using gold surface with AmGQD-CoTCPhOPc exhibited enhanced electrical conductivity. The fabricated electrochemical sensor displayed excellent analytical performance towards the detection of dopamine (DA), norepinephrine (NOR) and epinephrine (EP). The analytical parameters were linear within the concentration range of 1.0 to 50 μM with detection limits of 0.20 µM (DA), 0.45 µM (NOR), and 0.23 µM (EP) using S/N = 3. Furthermore, the fabricated electrochemical sensor exhibited good ability to suppress the background current due to ascorbic acid (AA), a major interferent during detection of DA, EP and NOR analytes. More importantly, the developed covalent electrochemical sensor was successfully utilized for the detection of catecholamine neurotransmitters in newborn calf serum samples with high recovery percentages.
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