化学
超临界流体色谱法
色谱法
二乙胺
醋酸铵
对映体
三氟乙酸
相(物质)
填充床
有机化学
气相色谱法
高效液相色谱法
作者
Daipayan Roy,Abhijit Tarafder,Larry Miller
标识
DOI:10.1016/j.chroma.2022.463216
摘要
The introduction of additives has revolutionized super/subcritical fluid chromatography (SFC) by expanding the range of compounds that could be analyzed by the technique. From being considered a mere extension of gas chromatography, incorporation of a modifier, and subsequently an additive has made SFC a workhorse for chiral separations. Additives are by far the smallest component of the SFC mobile phase but can result in changing the polarity and acidity of the mobile phase, suppression of ionization, deactivation of the stationary phase, and act as an ion pairing agent. A wide variety of compounds have been tested as additives including but not limited to diethylamine, trifluoroacetic acid, ammonium acetate, and water. This review summarizes the different role played by additives in the SFC mobile phase. Further this work aims to help the reader by critically evaluating different additives used in enantiomeric separations with packed column SFC.
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