立体中心
化学
邻接
催化作用
有机催化
有机化学
组合化学
对映选择合成
作者
Feng Zhou,Qi-Long Hu,Ke-Qiang Hou,Albert S. C. Chan,Xiao‐Feng Xiong
标识
DOI:10.1021/acs.joc.2c00950
摘要
A convenient strategy for the diastereoselective synthesis of α,β-diamino diacid derivatives bearing congested vicinal acyclic tetrasubstituted stereocenters via catalytic Mannich-type reactions of azlactones and 2-aminoacrylates was established. A diverse set of α,β-diamino diacid derivatives were synthesized in good to excellent yields and diastereoselectivities. Good enantioselectivity (up to 98:2 er) was achieved by employing the catalyst (DHQD)2PHAL in the subsequent asymmetric study.
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