交感神经系统
自主神经系统
肿瘤进展
免疫系统
癌变
转移
神经科学
血管生成
神经系统
生物
肿瘤微环境
医学
癌症研究
癌症
内分泌学
内科学
免疫学
心率
血压
作者
Zhifang Xu,Seiji Shioda,Masahisa Jinushi,Yutaka Kawakami,Hirokazu Ohtaki,Huimin Calista Lim,Shenjun Wang,Xue Zhao,Yangyang Liu,Dan Zhou,Yi Guo
标识
DOI:10.2174/1381612822666161025152942
摘要
Although evidence over the last 30 years suggests that the autonomic nervous system (ANS) mediates stress-induced allostatic and immune responses, the crucial role that it plays in the tumor micro-environment has only recently been reported. Here, we review the action of ANS signaling in this micro-environment. Emerging data suggest that primary tumors are innervated by the ANS which mediates stress-related effects on tumor progression. The activation of the sympathetic nervous system (SNS) takes advantage of neurotransmitters and neuropeptides from the innervating neural circuitry and/or hypothalamic-pituitary-adrenal axis glucocorticoids via their receptors to modulate the gene expression associated with oncogenesis, the proliferation and apoptosis of tumor cells, angiogenesis, and the tumor-associated immune response. The parasympathetic nervous system has also been implicated in some tumor types, but its contribution in the tumor micro-environment remains unclear. In addition to identifying the ANS signaling pathways involved in tumor progression, recent reports suggest that the ANS could be a potential biomarker to predict tumor progression, and have identified new pharmacological strategies, such as the use of β-adrenergic blockers, to inhibit tumor progression and metastasis by targeting this system. These findings are reviewed here. Keywords: Autonomic nervous system, tumor microenvironment, immune response, sympathetic nervous system, adrenergic signaling.
科研通智能强力驱动
Strongly Powered by AbleSci AI