High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in Individuals Without Previous Cardiovascular Conditions

医学 队列 内科学 胆固醇 队列研究 回廊的 疾病 人口学 观察研究 老年学 社会学
作者
Dennis T. Ko,David A. Alter,Helen Guo,Maria Koh,Geoffrey Lau,Peter C. Austin,Gillian L. Booth,William Hogg,Cynthia A. Jackevicius,Douglas S. Lee,Harindra C. Wijeysundera,John T. Wilkins,Jack V. Tu
出处
期刊:Journal of the American College of Cardiology [Elsevier BV]
卷期号:68 (19): 2073-2083 被引量:278
标识
DOI:10.1016/j.jacc.2016.08.038
摘要

The prognostic importance of high-density lipoprotein cholesterol (HDL-C) as a specific risk factor for cardiovascular (CV) disease has been challenged by recent clinical trials and genetic studies.This study sought to reappraise the association of HDL-C level with CV and non-CV mortality using a "big data" approach.An observational cohort study was conducted using the CANHEART (Cardiovascular Health in Ambulatory Care Research Team) dataset, which was created by linking together 17 different individual-level data sources. People were included if they were between 40 and 105 years old on January 1, 2008, living in Ontario, Canada, without previous CV conditions or severe comorbidities, and had an outpatient fasting cholesterol measurement in the year prior to the inception date. The primary outcome was cause-specific mortality.A total of 631,762 individuals were included. The mean age of our cohort was 57.2 years, 55.4% were women, and mean HDL-C level was 55.2 mg/dl. There were 17,952 deaths during a mean follow-up of 4.9 ± 0.4 years. The overall all-cause mortality rate was 8.1 per 1,000 person-years for men and 6.6 per 1,000 person-years for women. Individuals with lower HDL-C levels were more likely to have low incomes, unhealthy lifestyle, higher triglycerides levels, other cardiac risk factors, and medical comorbidities. Individuals with lower HDL-C levels were independently associated with higher risk of CV, cancer, and other mortality compared with individuals in the reference ranges of HDL-C levels. In addition, individuals with higher HDL levels (>70 mg/dl in men, >90 mg/dl in women) had increased hazard of non-CV mortality.Complex associations exist between HDL-C levels and sociodemographic, lifestyle, comorbidity factors, and mortality. HDL-C level is unlikely to represent a CV-specific risk factor given similarities in its associations with non-CV outcomes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
baoxiaozhai完成签到 ,获得积分10
1秒前
fy完成签到,获得积分10
2秒前
强公子完成签到,获得积分10
3秒前
9秒前
song完成签到 ,获得积分10
10秒前
怡然小蚂蚁完成签到 ,获得积分10
10秒前
小橙子完成签到,获得积分10
12秒前
SciGPT应助滴答采纳,获得10
12秒前
大气白翠完成签到,获得积分10
13秒前
确幸完成签到,获得积分10
13秒前
zjhzslq完成签到,获得积分10
13秒前
xdc发布了新的文献求助10
14秒前
ommphey完成签到 ,获得积分10
14秒前
牛哥还是强啊完成签到 ,获得积分10
15秒前
科研通AI2S应助屈岂愈采纳,获得10
16秒前
好名字完成签到,获得积分10
17秒前
kongzhiqiqi完成签到,获得积分10
18秒前
滴答完成签到 ,获得积分10
18秒前
浅浅殇完成签到,获得积分10
22秒前
23秒前
25秒前
滴答发布了新的文献求助10
28秒前
高高的天亦完成签到 ,获得积分10
29秒前
星空完成签到 ,获得积分10
30秒前
文艺的青旋完成签到 ,获得积分10
30秒前
青黛完成签到 ,获得积分10
37秒前
大橙子发布了新的文献求助10
41秒前
领导范儿应助科研通管家采纳,获得10
42秒前
量子星尘发布了新的文献求助10
46秒前
明钟达完成签到 ,获得积分10
54秒前
byyyy完成签到,获得积分10
57秒前
高高的哈密瓜完成签到 ,获得积分10
1分钟前
Rondab应助橙汁采纳,获得10
1分钟前
读书的时候完成签到,获得积分10
1分钟前
颜云尔完成签到,获得积分10
1分钟前
孤独雨梅完成签到,获得积分10
1分钟前
woobinhua完成签到 ,获得积分10
1分钟前
雪落你看不见完成签到,获得积分10
1分钟前
十月天秤完成签到,获得积分0
1分钟前
依文完成签到,获得积分20
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038128
求助须知:如何正确求助?哪些是违规求助? 3575831
关于积分的说明 11373827
捐赠科研通 3305610
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022