结晶
播种
亚稳态
姜黄素
再结晶(地质)
材料科学
产量(工程)
缓慢冷却
Crystal(编程语言)
色谱法
化学工程
结晶学
化学
热力学
有机化学
冶金
计算机科学
生物
物理
工程类
古生物学
生物化学
程序设计语言
作者
Marko Ukrainczyk,B.K. Hodnett,Åke C. Rasmuson
标识
DOI:10.1021/acs.oprd.6b00153
摘要
Purification of crude curcumin by up to four successive cooling crystallizations has been investigated for a wide variety of process conditions. For each crystallization step the influence of various processing conditions on crystal purity, polymorphic outcome, and crystal size and shape is reported. By an extensive number of experiments according to a statistical experimental design, the influence on cooling rate, seeding, seed polymorph, and agitation conditions has been identified. Slow cooling and seeding, particularly with the metastable Form II seed, significantly improves the purification. A correlation between product crystal size and purity is found. By tuning the crystallization parameters the number of recrystallization steps required to reach a certain purity can be reduced, which significantly increased the overall curcumin yield from 28% to 50%.
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