微卫星不稳定性
内科学
癌症
医学
阶段(地层学)
胃肠病学
肿瘤科
化疗
人口
疾病
癌变
爱泼斯坦-巴尔病毒感染
爱泼斯坦-巴尔病毒
病毒
免疫学
生物
基因
微卫星
等位基因
古生物学
环境卫生
生物化学
作者
Hua Shen,Meizuo Zhong,Chaofeng Tu,Howard L. McLeod,Xianli Yin,Daniel M. Rotroff,Todd C. Knepper,Howard L. McLeod,Chengfang Zhou,Shiyu Xie,Wei Li,Biaobo Xu,Yijing He
标识
DOI:10.1016/j.cca.2017.06.006
摘要
Epstein-Barr virus (EBV) and microsatellite instability (MSI) are associated with the carcinogenesis of many kinds of tumors, including gastric cancer (GC). However, the impact of EBV and MSI status on the prognosis of stage II and III GC is still unclear. The aim of this study was to find out the prognostic value of EBV and MSI status in a population of GC patients from Southern China. Patients were genotyped for EBV infection based on the detection of EBV DNA from the formalin-fixed paraffin-embedded (FFPE) specimens. Sequentially, MSI status was measured by direct sequencing. Clinical characteristics and overall survival (OS) were analyzed in 202 GC patients. Additionally, the association of EBV and MSI status with chemotherapy-based toxicity was analyzed in 324 GC patients. The survival analysis revealed EBV + patients had a poorer OS than EBV − patients (HR = 1.75, 95% CI: 1.08–2.82, FDR p = 0.04). This survival advantage for EBV − patients was also found in patients < 60 y (FDR p = 0.04) and patient with stage III disease (FDR p = 0.04). EBV infection and MSI status are associated with overall survival of gastric cancer patients. However, traditional chemotherapy showed no difference on outcome of patients in EBV and MSI subgroups.
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