化学
质子化
亲核细胞
萘
药物化学
亲核加成
立体化学
有机化学
离子
催化作用
作者
A. Lari,Mateusz B. Pitak,Simon J. Coles,Gregory J. Rees,Stephen P. Day,Mark E. Smith,John V. Hanna,John D. Wallis
摘要
The X-ray crystal structures of salts and zwitterionic Knoevenagel products from 1-dimethylamino-naphthalene-8-carbaldehyde show long N–C bonds between peri-groups which provide models for incomplete nucleophilic attack on a protonated carbonyl group and electron-deficient alkenes respectively. For the salts the N–C bonds lie in the range 1.625–1.638 Å with C–OH bonds intermediate in length between single and double bonds, while for the zwitterions the N–C bonds lie in the range 1.612–1.660 Å. The structural assignment of the former is supported by solid state 13C and 15N NMR studies on doubly isotopically-labelled material. Several zwitterions were converted to naphtha[1,8-bc]azepines by a mechanism involving the tertiary amino effect.
科研通智能强力驱动
Strongly Powered by AbleSci AI