赫斯1
生物
Wnt信号通路
Notch信号通路
转录因子
癌症研究
增强子
串扰
细胞生物学
上皮-间质转换
刺猬
祖细胞
刺猬信号通路
信号转导
干细胞
癌症
转移
遗传学
基因
物理
光学
作者
Aradhana Rani,Roseanna Greenlaw,Richard A. Smith,Christine Galustian
标识
DOI:10.1016/j.cytogfr.2016.03.010
摘要
Hairy and enhancer of split homolog-1 (HES1) is a part of an extensive family of basic helix-loop-helix (bHLH) proteins and plays a crucial role in the control and regulation of cell cycle, proliferation, cell differentiation, survival and apoptosis in neuronal, endocrine, T-lymphocyte progenitors as well as various cancers. HES1 is a transcription factor which is regulated by the NOTCH, Hedgehog and Wnt signalling pathways. Aberrant expression of these pathways is a common feature of cancerous cells. There appears to be a fine and complicated crosstalk at the molecular level between the various signalling pathways and HES1, which contributes to its effects on the immune response and cancers such as leukaemia. Several mechanisms have been proposed, including an enhanced invasiveness and metastasis by inducing epithelial mesenchymal transition (EMT), in addition to its strict requirement for tumour cell survival. In this review, we summarize the current biology and molecular mechanisms as well as its use as a clinical target in cancer therapeutics.
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